\u5b9e\u9a8c\u7814\u7a76\u8868\u660e\uff0c\u51cf\u5c11\u7761\u7720\u65f6\u95f4\u6216\u4e2d\u65ad\u7761\u7720\u4f1a\u5bfc\u81f4\u80f0\u5c9b\u7d20\u62b5\u6297\u548c\u8840\u7cd6\u6c34\u5e73\u5347\u9ad8\u3002\u524d\u77bb\u6027\u7814\u7a76\u7684\u7cfb\u7edf\u7efc\u8ff0\u548c\u835f\u8403\u5206\u6790\u4e00\u81f4\u53d1\u73b0\uff0c\u7761\u7720\u65f6\u95f4\u8f83\u77ed\u548c\u8f83\u957f\u4e0e2\u578b\u7cd6\u5c3f\u75c5(T2D)\u7684\u9ad8\u98ce\u9669\u76f8\u5173\u3002\u89c2\u5bdf\u6027\u7814\u7a76\u4e5f\u8868\u660e\uff0c\u5931\u7720\u3001\u767d\u5929\u5c0f\u7761\u548c\u7761\u7720\u7c7b\u578b\uff08\u504f\u597d\u665a\u7761\uff09\u4e0e\u8f83\u9ad8\u7684T2D\u98ce\u9669\u76f8\u5173\u3002\u7136\u800c\uff0c\u7531\u4e8e\u6b8b\u7559\u6df7\u6dc6\uff08\u4f8b\u5982\uff0c\u8eab\u4f53\u6d3b\u52a8\u548c\u996e\u98df\uff09\u548c\u53cd\u5411\u56e0\u679c\u5173\u7cfb\uff08\u4f8b\u5982\uff0c\u591c\u5c3f\u75c7\u548c\u795e\u7ecf\u6027\u75bc\u75db\uff09\u7684\u6f5c\u5728\u504f\u5dee\uff0c\u8fd9\u4e9b\u6570\u636e\u7684\u56e0\u679c\u5173\u7cfb\u5c1a\u4e0d\u660e\u786e\u3002<\/p>\n
\u5b5f\u5fb7\u5c14\u968f\u673a\u5316(MR)\u5206\u6790\uff0c\u4f7f\u7528\u9057\u4f20\u53d8\u5f02\u4f5c\u4e3a\u5de5\u5177\u53d8\u91cf\u6765\u8bc4\u4f30\u66b4\u9732\u5bf9\u7ed3\u679c\u7684\u56e0\u679c\u5f71\u54cd\uff0c\u6bd4\u4f20\u7edf\u7684\u89c2\u5bdf\u6027\u591a\u53d8\u91cf\u56de\u5f52\uff08MVR\uff09\u66f4\u4e0d\u5bb9\u6613\u6df7\u6dc6\u6216\u9006\u8f6c\u56e0\u679c\u5173\u7cfb\u3002\u56e0\u6b64\uff0c\u5728\u8bc4\u4f30\u56e0\u679c\u5173\u7cfb\u65f6\uff0c\u8fd9\u4e24\u79cd\u65b9\u6cd5\u7ed3\u679c\u7684\u4e00\u81f4\u6027\u589e\u52a0\u4e86\u53ef\u4fe1\u5ea6\u3002\u6700\u8fd1\u53d1\u8868\u7684\u53cc\u6837\u672cMR (2SMR)\u7814\u7a76\u53d1\u73b0\uff0c\u7761\u7720\u65f6\u95f4\u5bf9T2D\u548c\/\u6216\u76f8\u5173\u8840\u7cd6\u7279\u5f81\u7684\u56e0\u679c\u5f71\u54cd\u51e0\u4e4e\u6ca1\u6709\u4e00\u81f4\u7684\u8bc1\u636e\u3002\u4f46\u4e86\u89e3\u7761\u7720\u7279\u5f81\u5bf9\u666e\u901a\u4eba\u7fa4\u8840\u7cd6\u6c34\u5e73\u7684\u5f71\u54cd\u53ef\u80fd\u5bf9\u9884\u9632\u7cd6\u5c3f\u75c5\u4ea7\u751f\u6df1\u8fdc\u7684\u516c\u5171\u5065\u5eb7\u5f71\u54cd\u3002\u56e0\u6b64\u672c\u7814\u7a76\u65e8\u5728\u63a2\u8ba8\u7761\u7720\u7279\u5f81(\u4f8b\u5982\u5931\u7720\u3001\u7761\u7720\u65f6\u95f4\u3001\u767d\u5929\u55dc\u7761\u3001\u767d\u5929\u5c0f\u7761\u548c\u65f6\u578b) \u5bf9\u5e73\u5747\u8840\u7cd6\u6c34\u5e73\u7684\u5f71\u54cd\uff0c\u8fd9\u4e9b\u7279\u5f81\u7531\u7cd6\u5316\u8840\u7ea2\u86cb\u767d\uff08HbA1c\uff09\uff08\u4e3b\u8981\u7ed3\u5c40\uff09\u548c\u4e00\u822c\u4eba\u7fa4\u4e2d\u7684\u8461\u8404\u7cd6\uff08\u6b21\u8981\u7ed3\u5c40\uff09\u8bc4\u4f30\u3002<\/p>\n
\u57fa\u7ebf\u7279\u5f81<\/p>\n
\u5728336999\u540d\u53c2\u4e0e\u8005\u4e2d\uff0c\u5e73\u5747\uff08SD\uff09\u5e74\u9f84\u4e3a56.9\uff088.0\uff09\u5c81\uff0c54%\u4e3a\u5973\u6027;4.6%\u7684\u53c2\u4e0e\u8005\u60a3\u6709\u7cd6\u5c3f\u75c5\uff0c3%\u7684HbA1c\u226548 mmol\/mol\uff0c 0.5%\u8bca\u65ad\u4e3a\u7761\u7720\u547c\u5438\u6682\u505c\uff1b28%\u7684\u4eba\u62a5\u544a\u7ecf\u5e38\u6709\u5931\u7720\u75c7\u72b6\uff1b\u5e73\u5747\u7761\u7720\u65f6\u95f4\u4e3a7.2 (1.1)\u5c0f\u65f6\uff1b3%\u7684\u4eba\u8868\u793a\u767d\u5929\u7ecf\u5e38\u56f0\u5026\uff1b5%\u7684\u4eba\u62a5\u544a\u767d\u5929\u7ecf\u5e38\u5348\u7761\uff1b24%\u7684\u4eba\u62a5\u544a\u6709\u660e\u786e\u7684\u65e9\u6668\u7761\u7720\u7c7b\u578b\uff1b8%\u7684\u4eba\u62a5\u544a\u6709\u660e\u786e\u7684\u591c\u95f4\u7761\u7720\u7c7b\u578b\u3002\u65e0\u7cd6\u5c3f\u75c5\u60a3\u8005\u7cd6\u5316\u8840\u7ea2\u86cb\u767d\u4e2d\u4f4d\uff08\u56db\u5206\u4f4d\u6570\uff09\u4e3a35 (33\uff0c37)mmol\/mol\uff0c\u7cd6\u5c3f\u75c5\u60a3\u8005\u7cd6\u5316\u8840\u7ea2\u86cb\u767d\u4e2d\u4f4d(43\uff0c59)mmol\/mol;\u76f8\u5e94\u7684\u975e\u7a7a\u8179\u8840\u7cd6\u6c34\u5e73\u4e3a4.9 (4.6\uff0c5.3)mmol\/L\u548c6.6 (5.3\uff0c9.0)mmol\/L\u3002<\/p>\n
\u7761\u7720\u7279\u5f81\u4e0eHbA1c\u548c\u8461\u8404\u7cd6\u6c34\u5e73\u7684\u5173\u8054<\/p>\n
\u6240\u6709\u7684\u5206\u6790\u90fd\u6709\u4e00\u81f4\u7684\u8bc1\u636e\u8868\u660e\uff0c\u66f4\u9891\u7e41\u7684\u5931\u7720\u75c7\u72b6\uff08\u901a\u5e38vs.\u6709\u65f6\u6216\u5f88\u5c11\/\u4ece\u4e0d\uff09\u5bfc\u81f4\u66f4\u9ad8\u7684\u7cd6\u5316\u8840\u7ea2\u86cb\u767d\u6c34\u5e73\uff08MVR 0.05 [95% CI 0.04-0.06] SD\u5355\u4f4d;1SMRmain 0.52 (0.42 – -0.63\uff09;2 SMRmain 0.24 [0.11 – -0.36]\uff09;\u654f\u611f\u6027\u5206\u6790\u7684\u7ed3\u679c\u4e0e1SMRmain\u548c2SMRmain\u7684\u7ed3\u679c\u4e00\u81f4\uff08\u56fe1\uff09\u3002<\/p>\n
\u4f5c\u4e3a\u8fde\u7eed\u53d8\u91cf\uff0c\u8f83\u957f\u768424\u5c0f\u65f6\u7761\u7720\u65f6\u95f4\u4e0eMVR\uff08?0.006 [95% CI?0.010 -?0.003]SD\u5355\u4f4d\uff09\u548c1SMRmain\u5206\u6790\uff08?0.11[?0.15 -?0.07]\uff09\u4e2d\u8f83\u4f4e\u7684\u7cd6\u5316\u8840\u7ea2\u86cb\u767d\u6c34\u5e73\u76f8\u5173\uff0c\u4f46\u57281SMR\u591a\u6548\u6027\u9c81\u654f\u6027\u5206\u6790\u4e2d\u63a5\u8fd10\uff1b2SMR\u5206\u6790\u4e0d\u652f\u6301\u5f3a\u70c8\u7684\u56e0\u679c\u5173\u7cfb\uff08\u56fe2\uff09\u3002<\/p>\n
\u5728MVR\u5206\u6790\u4e2d\uff0c\u77ed\u7761\u7720\uff08\u22646 h\uff09\u548c\u957f\u7761\u7720\uff08\u22659 h\uff09\u4f5c\u4e3a\u4e8c\u5143\u53d8\u91cf\uff0c\u4e0e\u6b63\u5e38\u7761\u77207-8\u5c0f\u65f6\u7684\u4eba\u76f8\u6bd4\uff0c\u5747\u4e0eHbA1c\u8f83\u9ad8\u76f8\u5173(\u77ed\u7761\u77200.06 [95% CI 0.05-0.07] SD\u5355\u4f4d);\u957f\u7761\u77200.08[0.07-0.09])\u3002\u7136\u800c\uff0c\u57281SMRmain\u5206\u6790\u4e2d\uff0c\u6709\u8bc1\u636e\u8868\u660e\uff0c\u77ed\u7761\u7720\u65f6\u95f4\u4f1a\u589e\u52a0HbA1c\uff080.33[0.15-0.50]\uff09\uff0c\u800c\u957f\u7761\u7720\u65f6\u95f4\u4f1a\u964d\u4f4eHbA1c\uff08?0.50[?0.99 -?0.01]\uff09\u3002\u76f8\u5e94\u76841SMR\u591a\u6548\u6027-\u9c81\u68d2\u7075\u654f\u5ea6\u5206\u6790\u65b9\u5411\u76f8\u4f3c\uff0c\u4f46CI\u8f83\u5bbd\u30022SMR\u4f30\u8ba1\u4e0d\u652f\u6301\u77ed\u7761\u7720\u65f6\u95f4\u4e0eHbA1c\u7684\u4efb\u4f55\u5173\u8054\uff0c\u4f46\u8868\u660e\u8f83\u957f\u7684\u7761\u7720\u4e0e\u8f83\u4f4e\u7684HbA1c\u76f8\u5173(\u56fe2)\u3002<\/p>\n
MVR\u548c1SMRmain\u663e\u793a\u767d\u5929\u55dc\u7761\u66f4\u9891\u7e41\uff08MVR 0.086 [95% CI 0.079-0.093] SD\u5355\u4f4d\uff1b1SMRmain 0.14[0.02-0.27]\uff09\u548c\u65e5\u95f4\u5c0f\u7761\uff08MVR 0.087 [0.081-0.093];1SMRmain 0.09[0.03-0.14]\uff09\u4e0e\u8f83\u9ad8\u7684HbA1c\u6c34\u5e73\u76f8\u5173\uff0c\u5c3d\u7ba11SMR\u654f\u611f\u6027\u5206\u6790\uff0c\u4ee5\u53ca\u6240\u67092SMR\u5206\u6790\u90fd\u4e0d\u652f\u6301\u56e0\u679c\u6548\u5e94\uff08\u56fe3\uff09\u3002<\/p>\n
\u665a\u95f4\u504f\u597d\u4e0eMVR (0.008 [95% CI 0.006-0.011] SD\u5355\u4f4d\uff09\u548c1SMRmain(0.022[0.004-0.039])\u8f83\u9ad8\u7684\u7cd6\u5316\u8840\u7ea2\u86cb\u767d\u6c34\u5e73\u76f8\u5173\u3002\u7136\u800c\uff0c\u8fd9\u4e9b\u7ed3\u679c\u88ab\u8870\u51cf\uff0c\u5e76\u5728\u6240\u67091SMR\u591a\u6548\u6027\u9c81\u68d2\u7075\u654f\u5ea6\u5206\u6790\u548c2SMR\u5206\u6790\u4e2d\u5305\u542b\u96f6\u503c\uff08\u56fe4\uff09\u3002<\/p>\n
\u5728\u4e0d\u540c\u7684\u7814\u7a76\u8bbe\u8ba1\u53ca\u5176\u4e0d\u540c\u5047\u8bbe\u7684\u654f\u611f\u6027\u5206\u6790\u4e2d\uff0c\u4e00\u81f4\u7684\u8bc1\u636e\u8868\u660e\uff0c\u9891\u7e41\u7684\u5931\u7720\u75c7\u72b6\u4f1a\u589e\u52a0HbA1c\u6c34\u5e73\u3002\u652f\u6301\u5176\u4ed6\u7761\u7720\u7279\u5f81\u5bf9HbA1c\u548c\u8461\u8404\u7cd6\u6c34\u5e73\u7684\u56e0\u679c\u5f71\u54cd\u7684\u8bc1\u636e\u8f83\u5f31\u4e14\u4e0d\u592a\u4e00\u81f4\u3002<\/p>\n
\u603b\u4e4b\uff0c\u672c\u7814\u7a76\u901a\u8fc7MVR\u30011SMR\u548c2SMR\u7814\u7a76\u63d0\u51fa\u4e86\u5f3a\u6709\u529b\u7684\u8bc1\u636e\uff0c\u8868\u660e\u9891\u7e41\u5931\u7720\u75c7\u72b6\u5bfc\u81f4HbA1c\u5347\u9ad8\u3002\u56e0\u6b64\uff0c\u6539\u5584\u5931\u7720\u7684\u751f\u6d3b\u65b9\u5f0f\u548c\/\u6216\u836f\u7269\u5e72\u9884\u53ef\u80fd\u6709\u52a9\u4e8e\u9884\u9632T2D\u3002\u4e86\u89e3\u5931\u7720\u75c7\u72b6\u5bf9\u9ad8\u8840\u7cd6\u5f71\u54cd\u7684\u673a\u5236\u6709\u52a9\u4e8e\u786e\u5b9a\u6cbb\u7597\u7b56\u7565\u6216\u9884\u9632T2D\u7684\u65b0\u836f\u7269\u9776\u70b9\u3002<\/p>\n
\u539f\u6587\u6765\u6e90\uff1a<\/p>\n
Liu J\uff0c Richmond RC\uff0c Bowden J\uff0c Barry C\uff0c Dashti HS\uff0c Daghlas I\uff0c Lane JM\uff0c Jones SE\uff0c Wood AR\uff0c Frayling TM\uff0c Wright AK\uff0c Carr MJ\uff0c Anderson SG\uff0c Emsley RA\uff0c Ray DW\uff0c Weedon MN\uff0c Saxena R\uff0c Lawlor DA\uff0c Rutter MK. Assessing the Causal Role of Sleep Traits on Glycated Hemoglobin\uff1a A Mendelian Randomization Study. Diabetes Care. 2022 Apr 1;45(4)\uff1a772-781. doi\uff1a 10.2337\/dc21-0089. PMID\uff1a 35349659.<\/p>\n","protected":false},"excerpt":{"rendered":"
\u5b9e\u9a8c\u7814\u7a76\u8868\u660e\uff0c\u51cf\u5c11\u7761\u7720\u65f6\u95f4\u6216\u4e2d\u65ad\u7761\u7720\u4f1a\u5bfc\u81f4\u80f0\u5c9b\u7d20\u62b5\u6297\u548c\u8840\u7cd6\u6c34\u5e73\u5347\u9ad8\u3002\u524d\u77bb\u6027\u7814\u7a76\u7684\u7cfb\u7edf\u7efc\u8ff0\u548c…<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[1],"tags":[1363,166,185,201],"_links":{"self":[{"href":"https:\/\/www.shineu.com\/wp-json\/wp\/v2\/posts\/24965"}],"collection":[{"href":"https:\/\/www.shineu.com\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.shineu.com\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.shineu.com\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.shineu.com\/wp-json\/wp\/v2\/comments?post=24965"}],"version-history":[{"count":1,"href":"https:\/\/www.shineu.com\/wp-json\/wp\/v2\/posts\/24965\/revisions"}],"predecessor-version":[{"id":24966,"href":"https:\/\/www.shineu.com\/wp-json\/wp\/v2\/posts\/24965\/revisions\/24966"}],"wp:attachment":[{"href":"https:\/\/www.shineu.com\/wp-json\/wp\/v2\/media?parent=24965"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.shineu.com\/wp-json\/wp\/v2\/categories?post=24965"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.shineu.com\/wp-json\/wp\/v2\/tags?post=24965"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}